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Druggable Sphingolipid Pathways: Experimental Models and Clinical Opportunities.

Blaho VA. Adv Exp Med Biol. 2020. 1274:101-135. doi: 10.1007/978-3-030-50621-6_6.

Sphingosine 1-phosphate escapes the Catch-22 of sepsis prevention and mitigation therapies.

Blaho VA. EBioMedicine. 202. 59:102952. doi: 10.1016/j.ebiom.2020.102952.


Invited commentary on:

S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis.

Weigel C, Hüttner SS, Ludwig K, Krieg N, Hofmann S, Schröder NH, Robbe L, Kluge S, Nierhaus A, Winkler MS, Rubio I, von Maltzahn J, Spiegel S, and Gräler MH. EBioMedicine. 2020 58:102898. doi: 10.1016/j.ebiom.2020.102898.

Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.

Hilliard KA, Blaho VA, Jackson CD, and Brown CR. FASEB J. 2020. 34:2840-2852. doi: 10.1096/fj.201902014R. PMID: 31908031

LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction.

Lummis NC, Sánchez-Pavón P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, and Chun J. Sci Adv. 2019. eaax2011. doi: 10.1126/sciadv.aax2011.

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.

Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T. J Lipid Res. 2019. 60:1912-1921. doi: 10.1194/jlr.RA119000277.

Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis.

Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, and Ma X. Front Immunol. 2019. 10:404. doi: 10.3389/fimmu.2019.00404.

Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders.

Chun J, Kihara Y, Jonnalagadda D, and Blaho VA. Annu Rev Pharmacol Toxicol. 2019. 59:149-170. doi: 10.1146/annurev-pharmtox-010818-021358.

'Crystal' Clear? Lysophospholipid Receptor Structure Insights and Controversies.

Blaho VA and Chun J. Trends Pharmacol Sci. 2018. 39:953-966. doi: 10.1016/

An engineered S1P chaperone attenuates hypertension and ischemic injury.

Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, and Hla T. Sci Signal. 2017. eaal2722. doi: 10.1126/scisignal.aal2722. PMID: 28811382

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, and Hla T. Sci Signal. 2015. 8 (389):ra79. doi: 10.1126/scisignal.aaa2581. PMID: 26268607

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.

Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, and Hla T. Nature. 2015 Jul 16;523(7560):342-6. doi: 10.1038/nature14462.

Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.

Garris CS, Blaho VA, Hla T, and Han MH. Immunology. 2014 .142:347-53. doi: 10.1111/imm.12272.





Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.

Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, and Han MH. Nat Immunol. 2013. 14:1166-72. doi: 10.1038/ni.2730.

Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.

Blaho VA and Hla T. Chem Rev. 2011. 111:6299-320. doi: 10.1021/cr200273u.

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.

Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, and Hla T. J Clin Invest. 2011. 121:2290-300. doi: 10.1172/JCI45403.







Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics.

Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, and Hla T. J Exp Med. 2010. 207:1475-83. doi: 10.1084/jem.20091343.

Blue Journal of Lipid Research Cover with sphingolipid pathway cartoon showing S1P and ApoM

An update on the biology of sphingosine 1-phosphate receptors.

Blaho VA and Hla T. J Lipid Res. 2014. 55:1596-608.

doi: 10.1194/jlr.R046300.

Cancer Prevention Research Cover with immunohisto image of breast adipose crown-like structure

Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland.

Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, and Dannenberg AJ. Cancer Prev Res (Phila). 2011. 4:329-46. doi: 10.1158/1940-6207

Concise Guide to Pharmocology

2020 Blaho V, Chun J, Jones D, Jonnalagadda D, Kihara Y, Tan V. Lysophospholipid (S1P) receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Br J Pharmacol. 2019. 176:S21-S141. doi: 10.1111/bph.14748.


Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. Br J Pharmacol. 2017. 174:S1-S16. doi: 10.1111/bph.13882.

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