Publications
Druggable Sphingolipid Pathways: Experimental Models and Clinical Opportunities.
Blaho VA. Adv Exp Med Biol. 2020. 1274:101-135. doi: 10.1007/978-3-030-50621-6_6.
Sphingosine 1-phosphate escapes the Catch-22 of sepsis prevention and mitigation therapies.
Blaho VA. EBioMedicine. 202. 59:102952. doi: 10.1016/j.ebiom.2020.102952.
Invited commentary on:
S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis.
Weigel C, Hüttner SS, Ludwig K, Krieg N, Hofmann S, Schröder NH, Robbe L, Kluge S, Nierhaus A, Winkler MS, Rubio I, von Maltzahn J, Spiegel S, and Gräler MH. EBioMedicine. 2020 58:102898. doi: 10.1016/j.ebiom.2020.102898.
Hilliard KA, Blaho VA, Jackson CD, and Brown CR. FASEB J. 2020. 34:2840-2852. doi: 10.1096/fj.201902014R. PMID: 31908031
Lummis NC, Sánchez-Pavón P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, and Chun J. Sci Adv. 2019. eaax2011. doi: 10.1126/sciadv.aax2011.
Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.
Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T. J Lipid Res. 2019. 60:1912-1921. doi: 10.1194/jlr.RA119000277.
Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, and Ma X. Front Immunol. 2019. 10:404. doi: 10.3389/fimmu.2019.00404.
Chun J, Kihara Y, Jonnalagadda D, and Blaho VA. Annu Rev Pharmacol Toxicol. 2019. 59:149-170. doi: 10.1146/annurev-pharmtox-010818-021358.
'Crystal' Clear? Lysophospholipid Receptor Structure Insights and Controversies.
Blaho VA and Chun J. Trends Pharmacol Sci. 2018. 39:953-966. doi: 10.1016/j.tips.2018.08.006.
An engineered S1P chaperone attenuates hypertension and ischemic injury.
Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, and Hla T. Sci Signal. 2017. eaal2722. doi: 10.1126/scisignal.aal2722. PMID: 28811382
Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, and Hla T. Sci Signal. 2015. 8 (389):ra79. doi: 10.1126/scisignal.aaa2581. PMID: 26268607
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, and Hla T. Nature. 2015 Jul 16;523(7560):342-6. doi: 10.1038/nature14462.
Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.
Garris CS, Blaho VA, Hla T, and Han MH. Immunology. 2014 .142:347-53. doi: 10.1111/imm.12272.
Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, and Han MH. Nat Immunol. 2013. 14:1166-72. doi: 10.1038/ni.2730.
Blaho VA and Hla T. Chem Rev. 2011. 111:6299-320. doi: 10.1021/cr200273u.
Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.
Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, and Hla T. J Clin Invest. 2011. 121:2290-300. doi: 10.1172/JCI45403.
Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, and Hla T. J Exp Med. 2010. 207:1475-83. doi: 10.1084/jem.20091343.
An update on the biology of sphingosine 1-phosphate receptors.
Blaho VA and Hla T. J Lipid Res. 2014. 55:1596-608.
doi: 10.1194/jlr.R046300.
Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, and Dannenberg AJ. Cancer Prev Res (Phila). 2011. 4:329-46. doi: 10.1158/1940-6207
Concise Guide to Pharmocology
2020 Blaho V, Chun J, Jones D, Jonnalagadda D, Kihara Y, Tan V.
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Br J Pharmacol. 2019. 176:S21-S141. doi: 10.1111/bph.14748.
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.
Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. Br J Pharmacol. 2017. 174:S1-S16. doi: 10.1111/bph.13882.